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This was a difficult post to write as there is so much information about this subject to get your head around, so I have tried to keep it simple (honestly!) and have linked to websites so you can read more if you want to. I am not expert on this and am just trying to make sense of it myself so please look into it yourself rather than relying on this information when trying to solve your digestive problems. I am unsure about the validity of claims made by some websites and the products they promote (enzymes, probiotics and other supplements).

Firstly there are two things to define:

1. What is Leaky Gut Syndrome?

Leaky gut syndrome is not generally recognized by conventional physicians, but evidence is accumulating that it is a real condition that affects the lining of the intestines. The theory is that leaky gut syndrome (also called increased intestinal permeability), is the result of damage to the intestinal lining, making it less able to protect the internal environment as well as to filter needed nutrients and other biological substances. As a consequence, some bacteria and their toxins, incompletely digested proteins and fats, and waste not normally absorbed may “leak” out of the intestines into the blood stream. This triggers an autoimmune reaction, which can lead to gastrointestinal problems such as abdominal bloating, excessive gas and cramps, fatigue, food sensitivities, joint pain, skin rashes, and autoimmunity. The cause of this syndrome may be chronic inflammation, food sensitivity, damage from taking large amounts of nonsteroidal anti-inflammatory drugs (NSAIDS), cytotoxic drugs and radiation or certain antibiotics, excessive alcohol consumption, or compromised immunity.

This is a really good description of how a leaky gut can affect our health and the processes involved as well as some information about what to do about it.

Interestingly it suggests going on an elimination diet for a few weeks to allow things to calm down. I have done this and yes, my symptoms have calmed down, but I have not so far managed to move on to the next stage of reintroducing foods or improving my digestion, despite many attempts. I have been on what is basically an elimination diet for two years! I have put this down to my autonomic nervous system and it’s effects on the gut (it affects the spasms/motility) and is also responsible for my POTS symptoms. It may be that there is more to it and although I did take Kefir for a year (a kind of probiotic) I have not really focussed on these factors recently.

2. What is Gut Dysbiosis?

A frequent disorder (in ME/CFS) is dysbiosis, i.e. the overgrowth of pathogenic bacteria in the intestine… Chronic inflammation of the gut mucosa, resulting from dysbiosis, can lead to the development of leaky gut syndrome.

This quote is from the website  of the company providing the test that I did almost two years ago to see if I had Gut Dysbiosis. I had a moderate positive result.

On Dr Myhill’s site she explains that a positive test demonstrates not enough good bacteria and too much of a bad one:

Prevotella (bacteroides in the upper gut). These ferment to produce hydrogen sulphide. Hydrogen sulphide inhibits mitochondrial function directly. So a positive hydrogen sulphide urine test shows there is a severe gut dysbiosis with overgrowth of prevotella secondary to undergrowth of the goodies!

So, now you understand the basics, I am going to just focus on my personal issues and my plan to deal with this problem (still under construction!). So firstly, based on Dr Myhill’s information what am I doing right and wrong in terms of healing my leaky gut and its bad bacteria?

Things I am doing well:

  • Diet: While not Stone Age I have not been eating gluten grains or processed foods.
  • Diet: I eat lots of nuts, seeds and vegetables.
  • Diet:  I also eat fairly small meals and snack quite often as my blood sugar does not seem too stable (possibly due to the high GI foods I can digest).
  • Diet: I do eat spicy foods which I read is good for killing bad bugs – good news!
  • I have started to take digestive enzymes. These can help me to reintroduce foods that I have struggled to digest previously, and which will hopefully reduce the amount of undigested proteins leaking into my blood stream and therefore reduce bodily inflammation and immune system stress. They can also help to heal the gut wall, they say. See:
  • I take vitamin B12 which is good for stomach acid production (I think I read that somewhere, though maybe not on Dr Myhill’s site!)
  • I try to chew well.


Things that I am not doing well:

  • I take the contraceptive pill which suppresses the immune system and enourages yeast overgrowth
  • I am not on the Stone Age Diet (As a vegetarian I cannot really follow this diet but am not doing everything wrong, see above!). What I have not done brilliantly is that I have struggled to digest a lot of fibrous vegetables and carbohydrates, so my diet has been good for controlling IBS symptoms but been a bit too high GI. I don’t think this is good for weight management, feeling full/energy and I think possibly not great in terms of controlling bad bacteria in the gut (as good bacteria like/need fibre to feed off and break down in colon? I am a little unclear on this).
  • Also I do eat things with sugar in, though not huge amounts compared to many people. I don’t actually add it to anything (except honey – yummy!).
  • I need to take more vitamin C which can kill off bad bugs


What else can I do heal my Leaky Gut and improve my digestion?

Probiotics: Dr Myhill does not seem very convinced about taking probiotics, and also mentions not to eat sugar when taking Kefir (which she does like, it is a kind of probiotic that you make/grow yourself). (Did I take it for a year for nothing then as I ate sugar?).

This site has lots of information on probiotics.

I have bought two different probiotics and my plan is to have two weeks on a sugar-free diet and take them then for maximum effect (as less sugars for the Candida/yeast to feed on at the same time). I thought if I do it properly I should get some symptoms of die-off (feel terrible!) if I have yeast overgrowth so I should then know if it is an issue I have to take seriously longer term. I have been talking to other people with very bad Candida issues and I don’t think it is a big issue for me as I don’t have any obvious yeast issues. I think perhaps other types of bad bacteria are more the issue, but I will see what the sugar-free diet is like. I am unclear if a sugar-free diet is good for getting rid of other bad bacteria, not just yeast overgrowth. If so it could be a bit confusing.

L-Glutamine – I have bought some of this and have started to take it, but had diarrhea so have stopped for now but will try again.

Systemic enzymes: As well as enzymes to aid digestion, I have also started to take a high protease enzyme between meals as this is supposed to cleanse the blood of toxins that the liver has struggled with, and also reduce inflammation and kill bad bacteria. It seems to be making my stomach ache a bit more. I read to stop for a few days if this is the case then restart, which I have done, but it is still sore. It is often sore though, so perhaps I am misjudging it! There is lots of information on the Enzyme Stuff website as well as the websites of retailers.

Ginger tea is meant to be good for all things tummy – I am grating fresh ginger and making tea with it.

Hypochlorhydria: Stomach acid breaks down food into digestible form, if you don’t have enough then digestion will be very much impaired. It also controls bad bacteria etc. If you think you have low stomach acid then drinking cold water just before or after a meal is bad as it inhibits acid production. More on Hypochlorhydria here and here (the second link is a site about bad breath but has a good summary of the signs, issues and possible solutions to low stomach acid). Both sites mention Betaine HCL, which is an acid supplement. I have decided not to try this as it seems quite risky (being strong acid!) and would talk to my GP before taking it.

I am also trying not to drink too close to eating. I suspect my stomach acid is a bit on the low side and also I don’t want to dilute the action of the enzymes I am taking so it is best to let the food digest before flooding my stomach!  (I think common sense needs to be applied with this, especially for someone like me who needs to consume a lot of fluids for other health reasons, but it might be worth experimenting with if digestion is bad). There is some info here and here (see end of first paragraph).

There are various herbal anti-candida, anti-fungal, anti-viral type things you can take but they are either really expensive or seem to have some side effects/controversy so I am holding off on them for now, at least until I am convinced I have candida issues (I am not convinced yet, despite so many sources linking leaky gut with it!).

Additional websites to look at: This is an interesting article, though not easy to read or understand in parts. The list of “Trophic Therapies” about a third of the way down in interesting. It also lists tests that are available to help identify specific issues for the individual

my result...

my result...

Well after three minutes or so it looked like this – not actually a colour on the chart! it had changed colour a lot from yellow/orange to more like a pale version of the very dark positive colour (which, after a few more minutes, it turned into but they are very clear that only the result at 3 minutes counts!) so i think it is a “moderate positive”.
This is what is says on the leaflet:
The Neurotoxic Metabolite Test aims at detecting the presence of abnormal metabolites in the urine. These metabolites are related to the production of hydrogen sulfide (H2S). Although H2S is naturally present in the body, and plays some normal physiological functions, an excess production can be very detrimental. Overproduction of H2S may result from metabolic dysfunctions, but also from the overgrowth of certain bacteria in the gut (alteration of the normal intestinal flora = gut dysbiosis). Our preliminary results indicate that a strong proportion of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) patients present such dysbiosis, and test positive with the NMT test; but positivity may be associated with other conditions, related to intestinal dysfunction.
So it is not really a test for ME as the papers and hype suggested then, is it? BUT, if it leads to treatment of some aspect of our ill-health, it can only be a good thing and may improve quality of life… if it turns out it is the complete answer for some people, all the better.

Here is the article: new urine test for ME in the Telegraph 

here is what the ME Association say about it: 

I wonder if my diet and probiotics/Kefir regime have been helping my gut problems and perhaps have affected the result. I did stop taking the Kefir and probiotics a couple of weeks ago, although i continued to eat soya yogurts that have “yogurt cultures” in them as i thought they probably are not that potent and also i didn’t know how long it would take for the test to come and there are some things i can’t live without for long on my limited diet! My digestive “issues” have been so much improved over the last few weeks/months since i changed my diet – i wonder what the result would have been a few months ago!

All in all i am pleased that i do not seem to have a  “strong positive” result as no-one wants their body to be toxic do they!? I am going to keep up with the probiotics and hope that that can help. I don’t really see the point in going to my doctor about it – i know they won’t be able to do anything as the research is not even tested/published/recognised yet. I think i might have if it was a very positive result, just to see what they said. I may mention it to the POTS specialist when i see her next week – if i remember – as she is at least interested in ME issues and listens…

I am also going to look up “metabolic dysfunctions” which the test company also say can lead to a positive test result… i don’t know exactly what this means!

ME/CFS Awareness

ME/CFS Awareness


March 2017
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